RESULTS: During the 10-year period from 2000 through 2009, among a total of 384 patients with Kawasaki disease, 4 (3 females and 1 male; age range, 19-120 months) developed aseptic meningitis after IVIG. We report a case of a renal transplant patient who developed IVIG associated aseptic meningitis in the context of management of antibody-mediated rejection, four years after … Aseptic meningitis is a rare adverse effect of IVIG therapy and is a diagnosis of exclusion. Aseptic meningitis—along with cerebral vasospasm or ischemic encephalopathy—has been reported with intravenous immunoglobulin (IVIg) therapy. Aseptic meningitis was first reported as a possible side effect of IVIG in 1988. Jarius et al strongly suggest that in vivo activation of TNF-alpha–primed neutrophils by atypical antineutrophil cytoplasmic antibodies (ANCAs) of IVIg may contribute to these side effects. METHODS: A retrospective analysis of the medical records of patients with KD who developed aseptic meningitis after IVIG treatment was performed. 5 Since then at least 36 cases have been documented, either in the medical literature or as reported to the Food and Drug Administration. We have found that running the infusion slower and with more fluids decreases the chances of the aseptic menegitis. Other adverse effects include acute renal failure, aseptic meningitis, hemolysis, transfusion-related acute lung injury, and transmission of blood-borne infections. Aseptic meningitis often has a similar presentation to that of bacterial meningitis (ie, fever, headache, altered mental status, stiff neck, photophobia), which can be a life-threatening illness. Emily In our patient, the diagnosis of IVIG-associated aseptic meningitis was based on following points. The first two times, I did not get AM, the last two I did. The inflammation can … Anti-neutrophil antibodies in some IVIG brands may also play part in pathogenesis of IVIG-induced aseptic meningitis. I have developed aseptic menengitis 2x from IVIG and had to be hospitalized both times. Symptoms, which are severe and similar to meningitis, usually begin a few hours after treatment but can occur up to two days later. I had Ivig 4 times total. Meningitis is a condition that causes the tissues covering your brain and spinal cord to become inflamed. I had asceptic Meningitis 2 times from Ivig. Medical professionals these days are more concerned about instant treatments for viral diseases due to ivig side effects aseptic meningitis. The most severe form of IG-related headache comes from aseptic meningitis, and in fact, patients with a history of migraines appear to be more susceptible to aseptic meningitis. 5 In most of the reported cases, signs and symptoms occurred within 48 h of IVIG infusion, but some cases presented as … The management of antibody-mediated rejection in renal transplant recipients involves plasmapheresis with IVIG. After the 2nd time they were skeptical to give me IVIG again. Although, it is advised to get kids vaccinated on time so that they can stay safe from such diseases but the adults also need to … What is aseptic meningitis? The last two were a gammagaurd and the first two were carimune (I think I spelled that right). Since then I have had numerous IVIG’s with little to no side effects. Though aseptic meningitis has also been reported as a serious complication following IVIG therapy, it is a self-limiting condition and easily manageable. 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